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Cat. No. MOTSC | 10 mg per vial | Single compound
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Mitochondrial-derived peptide (research designation MOTS-c), supplied as a single 10 mg lyophilized research aliquot.
Research use only. Not for human or animal use.
| Form | Lyophilized powder |
|---|---|
| CAS Number | 1627580-64-6 |
| Total Compound Content | 10 mg per vial |
| Chemical Formula | C101H152N28O22S2 |
|---|---|
| Synonyms | MOTS-c; mitochondrial open reading frame of the 12S rRNA type-c |
| Molar Mass | 2174.6 g/mol |
| PubChem CID | 146675088 ↗ |
Published experiments examine mitochondrial-to-nuclear communication, folate-dependent metabolism, AMPK signaling, and responses to metabolic stress. The Research tab links to the studies underlying this context.
Published work describes changes in folate-dependent metabolism and purine synthesis associated with AMPK activation. Separate experiments report movement of MOTS-c into the nucleus during metabolic stress. These are mechanisms under investigation in the cited models.
The authors identified MOTS-c within mitochondrial DNA and examined folate-cycle and purine-metabolism changes associated with AMPK activation in their experimental models.
Lee C et al. · Cell Metab · 2015 · PMID 25738459This study tracked MOTS-c moving into the nucleus during metabolic stress and investigated changes in nuclear gene expression and AMPK-dependent signaling.
Kim KH et al. · Cell Metab · 2018 · PMID 29983246The researchers examined bone and osteoclast measurements in ovariectomized mice and investigated whether AMPK inhibition altered the response observed with MOTS-c.
Ming W et al. · Biochem Biophys Res Commun · 2016 · PMID 27237975This review brings together work on mitochondrial-to-nuclear communication, metabolic regulation, and stress responses. It provides context for the individual experiments above.
Wan W et al. · J Transl Med · 2023 · PMID 36670507These publications describe their own experimental materials and models, not testing of this product. Research-use policy →
